Leesburg is a city in Lake County, Florida, United States. As of 2020, the population had exactly 27,000 residents. Leesburg is in central Florid…Leesburg is a city in Lake County, Florida, United States. As of 2020, the population had exactly 27,000 residents. Leesburg is in central Florida, between Lake Harris and Lake Griffin, at the head of the Ocklawaha River. It is part of the Orlando–Kissimmee–Sanford Metropolitan Statistical Area.
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