But Messi, 36, was substituted after 37 minutes of Inter Miami's 4-0 win at home against Toronto on Wednesday. The Argentina superstar missed Miami’s defeat at Atlanta last weekend and that came after he also missed Argentina’s 3-0 win in Bolivia over the recent international break due to an unspecified injury.

Orlando City: After losing to NYCFC midweek, Orlando can clinch a playoff spot with a point in this match, and few things would feel better than doing it against their in-state rivals. While they won't get to face Messi for the second time this season, it does give the Lions a better shot at getting the job done and securing a playoff spot.

Inter Miami must do without a key trio of players when they face Orlando City at Exploria Stadium in MLS on Sunday.

Inter Miami host the Houston Dynamo in the U.S. Open Cup final on Wednesday, September 27, as Lionel Messi is in a race to be fit for the showpiece event.

Inter Miami vs. Orlando City will be broadcast exclusively via live stream on the MLS Season Pass from Apple TV+. It will not air on cable TV. Inter Miami is coming off a decisive 4-0 win over Toronto.